When I say depressed I don't mean in a suicidal emo like fashion. When you're not exactly happy, and don't feel like listening to the happiest cheery stuff. Hopefully this thread will help introduce people to other artists and their songs.

Here's a few tunes that I feel sooth the soul:

And So It Goes: Billy Joel
(What's So Funny Bout) Peace, Love & Understanding - Elvis Costello
The Thrill Is Gone - BB King
God's Gonna Cut You Down - Johnny Cash
Turn The Page - Bob Seger (and the Metallica cover)
Love Reign O'er Me - The Who
God Was Never On Your Side - Motorhead
More Than This - Roxy Music
The Ghost of Tom Joad - Bruce Springsteen
Hurt - Johnny Cash
The Downeaster Alexa - Billy Joel
Dust in the Wind (GNR version)
There's No Way Out of Here - David Gilmour
Desperado - Eagles
Georgia on my Mind - Ray Charles & The Count Basie Orchestra
The Crow and the Butterfly - Shinedown
Gran Torino - Clint Eastwood & Jamie Culum

Thats what I would currently listen to, but my tastes vary from time to time. If I think of any other important ones, I'll post them.